[Erythropoiesis in the mouse following chronic administration of small doses of busulphan (author's transl)]

Rev Esp Fisiol. 1977 Sep;33(3):163-7.
[Article in Spanish]

Abstract

After both splenectomized and non-splenectomized mice had received a total amount of five doses of Busulfan at a rate of 0.14 mg/48 h, the recovery of their erythropoietic organs through the addition of 59Fe was investigated, after the cytostatic treatment had been cut off. In the non-splenectomized animals recovery was clear, keeping high 59Fe uptake values, significantly above normal, throughout the 21 days of the experiment. In the splenectomized mice, 59Fe uptake reached a peak of 38 per cent three days after the supply had been cut off, and from then on it descended to subnormal values.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Busulfan / administration & dosage
  • Busulfan / pharmacology*
  • Erythropoiesis / drug effects*
  • Female
  • Iron / metabolism*
  • Mice
  • Spleen / physiology*
  • Splenectomy
  • Stimulation, Chemical

Substances

  • Iron
  • Busulfan