The aim of this study was the evaluation of the measurement of sCD23 and IgE levels before and after immunotherapy. The research was conducted in a group of 23 children aged 6 to 18 years with pollinosis diagnosed on the basis of the patient's history, increased IgE level and positive skin tests with pollen allergens. The control group consisted of 10 healthy children in the same age with normal IgE level. The treated children were examined before and 6 weeks after immunotherapy. Before immunotherapy in both groups of children (with the high and medium IgE level) the sCD23 concentration was statistically higher (level of significance p < 0.001) compared to the sCD23 level in the healthy children. After immunotherapy we observed significant decrease of the sCD23 level. We did not found correlation between sCD23 and IgE in children with pollinosis before and after immunotherapy.