Saquinavir interaction with midazolam: pharmacokinetic considerations when prescribing protease inhibitors for patients with HIV disease

AIDS. 1997 Feb;11(2):268-9.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / therapeutic use
  • Cytochrome P-450 Enzyme System / metabolism
  • Drug Interactions
  • HIV Infections / drug therapy*
  • HIV Protease Inhibitors / administration & dosage
  • HIV Protease Inhibitors / pharmacokinetics
  • HIV Protease Inhibitors / therapeutic use*
  • Humans
  • Hypnotics and Sedatives / therapeutic use*
  • Lamivudine / administration & dosage
  • Lamivudine / therapeutic use
  • Liver / enzymology
  • Male
  • Midazolam / therapeutic use*
  • Saquinavir / administration & dosage
  • Saquinavir / pharmacokinetics
  • Saquinavir / therapeutic use*
  • Trimethoprim, Sulfamethoxazole Drug Combination / administration & dosage
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
  • Zidovudine / administration & dosage
  • Zidovudine / therapeutic use

Substances

  • Anti-HIV Agents
  • HIV Protease Inhibitors
  • Hypnotics and Sedatives
  • Lamivudine
  • Zidovudine
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Cytochrome P-450 Enzyme System
  • Saquinavir
  • Midazolam