Furanocoumarins with affinity to brain benzodiazepine receptors in vitro

Phytochemistry. 1997 Mar;44(6):1121-4. doi: 10.1016/s0031-9422(96)00703-0.

Abstract

Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding, Competitive
  • Brain / metabolism*
  • Coumarins / chemistry
  • Coumarins / isolation & purification*
  • Coumarins / pharmacology
  • Diazepam / metabolism*
  • Furans
  • Magnetic Resonance Spectroscopy
  • Male
  • Medicine, Chinese Traditional
  • Molecular Structure
  • Plant Roots
  • Plants, Medicinal*
  • Rats
  • Rats, Wistar
  • Receptors, GABA-A / drug effects
  • Receptors, GABA-A / metabolism*

Substances

  • Coumarins
  • Furans
  • Receptors, GABA-A
  • phellopterin
  • Diazepam