Abstract
This article is an overview of peptide growth factors, their receptors, and signal-transduction pathways that play a role in bladder cancer. Included in this overview are epidermal growth factor receptor and its ligands, erbB2, fibroblast growth factors, insulin-like growth factor, the transferrin receptor, and transforming growth factor-beta. The use of growth factors or growth factor receptors for diagnostic and therapeutic interventions is also discussed.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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ErbB Receptors / metabolism
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Fibroblast Growth Factors / metabolism
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Genes, erbB-2
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Growth Substances / metabolism*
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Humans
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Receptors, Transferrin / metabolism
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Somatomedins / metabolism
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Transforming Growth Factor beta / metabolism
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Urinary Bladder Neoplasms / genetics
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Urinary Bladder Neoplasms / metabolism*
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Urinary Bladder Neoplasms / therapy
Substances
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Growth Substances
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Receptors, Transferrin
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Somatomedins
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Transforming Growth Factor beta
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Fibroblast Growth Factors
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ErbB Receptors