Listeria monocytogenes infection in mice treated with pentoxifylline

Zentralbl Bakteriol. 1997 Apr;285(4):491-500. doi: 10.1016/s0934-8840(97)80110-7.

Abstract

The course of L. monocytogenes infection was followed in mice treated with pentoxifylline (POF), a known inhibitor of endogenous tumor necrosis factor (TNF) formation. Administration of POF caused a delay in L. monocytogenes elimination which was probably related to a reduction the listericidal activity of macrophages and to an attenuation of delayed type hypersensitivity (DTH) to Listeria antigens. In spite of this, some POF-treated mice were protected from lethal effects of virulent L. monocytogenes bacteria.

MeSH terms

  • Animals
  • Cells, Cultured
  • Disease Models, Animal
  • Female
  • Hypersensitivity, Delayed
  • Listeriosis / drug therapy*
  • Listeriosis / microbiology
  • Macrophages, Peritoneal / cytology
  • Macrophages, Peritoneal / immunology
  • Mice
  • Mice, Inbred BALB C
  • Pentoxifylline / therapeutic use*
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Tumor Necrosis Factor-alpha
  • Pentoxifylline