Abstract
Cofilin, a ubiquitous 15,000 M(r) protein, plays a central role in regulating cytoskeletal dynamics. Cofilin binds to actin monomers and filaments, and has a pH-dependent actin severing activity. The structure will allow for a detailed analysis of cofilin function.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Actin Depolymerizing Factors
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Amino Acid Sequence
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Crystallography, X-Ray
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Microfilament Proteins / chemistry*
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Models, Molecular
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Molecular Sequence Data
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Nerve Tissue Proteins / chemistry*
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Protein Structure, Secondary*
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Saccharomyces cerevisiae / chemistry*
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Sequence Homology, Amino Acid
Substances
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Actin Depolymerizing Factors
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Microfilament Proteins
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Nerve Tissue Proteins