The role of boron MRI in boron neutron capture therapy

J Neurooncol. 1997 May;33(1-2):153-61. doi: 10.1023/a:1005793903512.

Abstract

Boron magnetic resonance imaging (MRI) and spectroscopy (MRS) are being developed for use in boron neutron capture therapy (BNCT). With continued development, boron MRI may be used to locate BNCT agents in vivo, evaluate the pharmacokinetics of BNCT agents, and aid in treatment planning.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Borohydrides / analysis*
  • Borohydrides / pharmacokinetics
  • Boron Neutron Capture Therapy / methods*
  • Boron*
  • Brain / metabolism*
  • Brain Neoplasms / metabolism*
  • Brain Neoplasms / radiotherapy*
  • Brain Neoplasms / surgery
  • Humans
  • Magnetic Resonance Imaging*
  • Magnetic Resonance Spectroscopy
  • Rats
  • Rats, Inbred F344
  • Sulfhydryl Compounds / analysis*
  • Sulfhydryl Compounds / pharmacokinetics

Substances

  • Borohydrides
  • Sulfhydryl Compounds
  • mercaptoundecahydrododecaborate
  • Boron