Lamotrigine therapy in infantile neuronal ceroid lipofuscinosis (INCL)

Neuropediatrics. 1997 Feb;28(1):77-9. doi: 10.1055/s-2007-973676.

Abstract

Since 1990, altogether 16 INCL patients received lamotrigine (LTG) because of intractable epilepsy. The response to LTG was favorable in 15/16 children. The severity of seizures decreased significantly in 15/16 patients, the frequency of seizures decreased in 14/16, and the effects were maintained. In addition, LTG had a beneficial effect on the well-being of 14/16 children. LTG failed to maintain it's efficacy in monotherapy. No severe side effects were found.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anticonvulsants / therapeutic use*
  • Child
  • Child, Preschool
  • Drug Therapy, Combination
  • Electroencephalography / drug effects
  • Follow-Up Studies
  • Humans
  • Infant
  • Lamotrigine
  • Neurologic Examination / drug effects
  • Neuronal Ceroid-Lipofuscinoses / drug therapy*
  • Treatment Outcome
  • Triazines / therapeutic use*

Substances

  • Anticonvulsants
  • Triazines
  • Lamotrigine