Coexistence of mu-opioid receptor-like and substance P-like immunoreactivities in the cat dorsal root ganglionic neurons

Y Lü; H X Zheng; Y Q Ding; L W Gong; B Z Qin; J S Li

Coexistence of mu-opioid receptor-like and substance P-like immunoreactivities in the cat dorsal root ganglionic neurons

J Hirnforsch. 1997;38(2):243-6.

Authors

Y Lü¹, H X Zheng, Y Q Ding, L W Gong, B Z Qin, J S Li

Affiliation

¹ Department of Anatomy, Fourth Military Medical University Xi an, People's Republic of China.

PMID: 9176736

Abstract

Coexistence of mu-opioid receptor (MOR)-like immunoreactivity (LI) and substance P (SP)-LI in the neurons of the cat dorsal root ganglia (DRG) was examined by a double immunofluorescence histochemical method. Approximately 91% of SP-LI neurons in the DRG showed MOR-LI. However, SP-LI was exhibited in approximately 28% of the neurons labeled with MOR-LI. These morphological findings indicated that the MOR exist on most of the primary afferent SP-containing terminals, and suggest that MOR may regulate SP release from the primary afferent terminals in the cat dorsal horn.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Afferent Pathways / cytology
Animals
Cats
Fluorescent Antibody Technique
Ganglia, Spinal / cytology*
Immunohistochemistry
Male
Nerve Endings / ultrastructure
Neurons / cytology*
Receptors, Opioid, mu / analysis*
Substance P / analysis*

Substances

Receptors, Opioid, mu
Substance P