Abstract
Homoretinoic and bishomoretinoic acid have been synthesized. Fast reaction under ultrasonic activation (Wolff rearrangement, saponification) produced compounds in high yields. Only the bishomo analogue exhibits a significative activity alone and a synergistic effect with vitamin D3 on the differentiation of U937 leukemic cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Cell Differentiation / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Muramidase / metabolism
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Phagocytosis / drug effects
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Tretinoin / analogs & derivatives*
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Tretinoin / chemical synthesis*
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Tretinoin / pharmacology
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Tretinoin
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Muramidase