[The need of prolonged BCG treatment in superficial bladder cancer is suggested by the development of a peripheral immune response induced by BCG]

H Shekarsarai; A R Zlotta; A Drowart; J P Van Vooren; M De Cock; M Pirson; K Palfliet; F Jurion; A Vanonckelen; J Simon; C C Schulman; K Huygen

[The need of prolonged BCG treatment in superficial bladder cancer is suggested by the development of a peripheral immune response induced by BCG]

Acta Urol Belg. 1997 Mar;65(1):1-4.

[Article in French]

Authors

H Shekarsarai¹, A R Zlotta, A Drowart, J P Van Vooren, M De Cock, M Pirson, K Palfliet, F Jurion, A Vanonckelen, J Simon, C C Schulman, K Huygen

Affiliation

¹ Département dUrologie, Hôpital Universitaire Erasme, Bruxelles, Belgique.

PMID: 9245197

Abstract

Optimal duration of immunotherapy treatment by BCG for the prevention of recurrences of superficial bladder cancer is still unknown. We have studied the evolution and duration of the cellular immunity response at the peripheral level after BCG intravesical instillations. Our results show that immunity activation after BCG is of short duration and don't take more than 6 months. Our results support, strengthen and partially allow to explain the utility of maintenance treatment by BCG following 6-weekly instillations.

Publication types

Clinical Trial
English Abstract

MeSH terms

Adjuvants, Immunologic / therapeutic use*
Aged
BCG Vaccine / therapeutic use*
Combined Modality Therapy
Cytokines / biosynthesis
Endoscopy
Female
Humans
Lymphocyte Activation
Male
Neoplasm Recurrence, Local / prevention & control
Urinary Bladder Neoplasms / immunology
Urinary Bladder Neoplasms / surgery
Urinary Bladder Neoplasms / therapy*

Substances

Adjuvants, Immunologic
BCG Vaccine
Cytokines