We sought to determine if differences exist between interventional and noninterventional cardiologists in the perception of risk of revascularization procedures and to compare the physicians' estimates with a computer-based predictor formula from a large regional database. We found that interventional cardiologists perceived greater risk of percutaneous transluminal coronary angioplasty-related morbidity and mortality than noninterventionalists and that these differences were accentuated in female patients, the elderly, and the most seriously ill patients.