Changes in amyloid precursor protein and apolipoprotein E immunoreactivity following ischemic brain injury in rat with long-term survival: influence of idebenone treatment

Neurosci Lett. 1997 Aug 29;232(2):95-8. doi: 10.1016/s0304-3940(97)00571-5.

Abstract

We observed in extra- and intracellular space accumulation of different fragments of amyloid precursor protein (APP) and apolipoprotein E (Apo E) in rat brain after cardiac arrest with long-term survival. Idebenone treatment did not affect APP and Apo E alterations in this condition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / metabolism
  • Amyloid beta-Protein Precursor / metabolism*
  • Animals
  • Apolipoproteins E / metabolism*
  • Benzoquinones / pharmacology*
  • Brain Ischemia / metabolism*
  • Cerebral Cortex / blood supply
  • Cerebral Cortex / metabolism
  • Female
  • Hippocampus / blood supply
  • Hippocampus / metabolism*
  • Rats
  • Rats, Wistar
  • Ubiquinone / analogs & derivatives

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Apolipoproteins E
  • Benzoquinones
  • Ubiquinone
  • idebenone