Contour-based registration technique to differentiate between task-activated and head motion-induced signal variations in fMRI

Magn Reson Med. 1997 Sep;38(3):470-6. doi: 10.1002/mrm.1910380315.

Abstract

Data acquired using functional magnetic resonance imaging are often contaminated by head motion. As a result, optimal information regarding task-induced (or resting-state) signal changes cannot be extracted. Intensity-based registration methods, including intensity correlation or minimum intensity variance techniques, are widely used to register two or more images. It is shown here that intensity-based registration cannot accurately register two or more images in the presence of local intensity changes arising from functional magnetic resonance, fMRI, signals. In this paper, we present a contour-based technique that can be used not only for a more robust registration, but also to help differentiate between task-induced and motion-induced signal changes. Results obtained using both phantom and human brain images demonstrate advantages of this technique compared with a conventional intensity registration technique.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Artifacts
  • Female
  • Head Movements*
  • Humans
  • Image Enhancement / methods*
  • Image Processing, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Models, Theoretical