Multisubstrate analogue based on 5,8,10-trideazafolate

Bioorg Med Chem. 1997 Sep;5(9):1853-7. doi: 10.1016/s0968-0896(97)00124-7.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Division / drug effects
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / metabolism
  • Glutamates / chemical synthesis*
  • Glutamates / chemistry*
  • Glutamates / metabolism
  • Humans
  • Hydroxymethyl and Formyl Transferases / antagonists & inhibitors
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Phosphoribosylaminoimidazolecarboxamide Formyltransferase
  • Phosphoribosylglycinamide Formyltransferase
  • Quinazolines / chemical synthesis*
  • Quinazolines / chemistry*
  • Quinazolines / metabolism
  • Spectrometry, Mass, Fast Atom Bombardment
  • Substrate Specificity
  • Tumor Cells, Cultured

Substances

  • Enzyme Inhibitors
  • Glutamates
  • N-(4-(3-(2-amino-3,4-dihydro-4-oxoquinazol-6-yl)-((8-phosphono)-1-(octanoyloxy))prop-2-yl)benzoyl)glutamic acid
  • Quinazolines
  • Hydroxymethyl and Formyl Transferases
  • Phosphoribosylglycinamide Formyltransferase
  • Phosphoribosylaminoimidazolecarboxamide Formyltransferase