Probabilistic diagnosis in linkage analysis of bipolar disorder: putting weights on the fringe

Genet Epidemiol. 1997;14(6):693-8. doi: 10.1002/(SICI)1098-2272(1997)14:6<693::AID-GEPI24>3.0.CO;2-K.

Abstract

We explored the utility of probabilistic weighting of fringe phenotypes in linkage analysis of bipolar disorder for the GAW10 chromosome 18 data. Four liability classes were assigned probabilistic weights based on the estimated probability that the case was a true bipolar. The weights were incorporated in parametric and nonparametric, single and multipoint analyses.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bipolar Disorder / diagnosis
  • Bipolar Disorder / epidemiology
  • Bipolar Disorder / genetics*
  • Chromosomes, Human, Pair 18*
  • Genetic Linkage*
  • Humans
  • Lod Score
  • Models, Genetic*
  • Models, Statistical*
  • Phenotype
  • Prevalence
  • Probability*
  • Risk Factors
  • Statistics, Nonparametric