Prior segregation analysis and the power to detect linkage

Genet Epidemiol. 1997;14(6):755-60. doi: 10.1002/(SICI)1098-2272(1997)14:6<755::AID-GEPI32>3.0.CO;2-N.

Abstract

Complex parametric segregation and linkage analysis was performed on the simulated quantitative trait Q1 for all 200 replicates of the nuclear families data set. The segregation analysis inferred a major gene in 46% of the replicates. Among all replicates, including those that rejected a major gene, the power to detect suggestive linkage to any of three loci affecting Q1 was 0.600 and the false positive rate was 0.002. Among the replicates where a major gene was found, the power to detect suggestive linkage was 0.652 and the false positive rate was also 0.002. Thus, for purposes of linkage to this complex trait, a prior segregation then linkage analysis approach located a gene in 30% of all replicates, whereas a linkage only approach located a gene in 60% of all replicates.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Computer Simulation*
  • Female
  • Genetic Linkage*
  • Humans
  • Likelihood Functions
  • Lod Score
  • Male
  • Meiosis / genetics*
  • Models, Genetic*
  • Nuclear Family*
  • Predictive Value of Tests
  • Quantitative Trait, Heritable*