Treatment of gestational trophoblastic disease

Gen Diagn Pathol. 1997 Nov;143(2-3):159-71.

Abstract

Gestational trophoblastic disease (GTD) forms a spectrum of illness from the borderline malignancy of hydatidiform mole to the highly aggressive behaviour of choriocarcinoma. In the past, many women have died from this group of disorders. However, during the last 45 years highly effective chemotherapy regimens have been developed which can be appropriately tailored to the individual patient's risk of becoming resistant to the treatment. As a result, the management of GTD is one of the modern success stories in oncology. Today, with an integrated approach to management few women die from their trophoblastic tumours.

Publication types

  • Review

MeSH terms

  • Adult
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / secondary
  • Choriocarcinoma / diagnostic imaging
  • Chorionic Gonadotropin / blood
  • Contraception
  • Drug Resistance, Neoplasm
  • Female
  • Follow-Up Studies
  • Hemorrhage / etiology
  • Humans
  • Hydatidiform Mole / complications
  • Hydatidiform Mole / drug therapy
  • Hydatidiform Mole / pathology
  • Pregnancy
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Trophoblastic Neoplasms / blood
  • Trophoblastic Neoplasms / complications
  • Trophoblastic Neoplasms / drug therapy*
  • Trophoblastic Neoplasms / pathology
  • Trophoblastic Tumor, Placental Site / drug therapy
  • Uterine Neoplasms / blood
  • Uterine Neoplasms / complications
  • Uterine Neoplasms / diagnostic imaging
  • Uterine Neoplasms / drug therapy*
  • Uterine Neoplasms / pathology

Substances

  • Chorionic Gonadotropin