Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu(II) complex

Environ Health Perspect. 1997 Dec;105 Suppl 6(Suppl 6):1459-62. doi: 10.1289/ehp.97105s61459.

Abstract

When cells or DNA is exposed to ionizing radiation, the radicals produced in the irradiated sample will modify the base-pair region of the double strands. Effects of 1,2-dihydroxy-9,10-anthraquinone (DHA) and its Cu(II) complex on the radiation-induced modification of double-strands in calf thymus DNA were studied using ethidium bromide as a fluorescent probe. Our results show that the Cu(II)-DHA complex is more efficient in modifying the base-pair region in double-stranded DNA compared to free DHA.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthraquinones / toxicity*
  • Cattle
  • DNA / radiation effects*
  • DNA Damage / drug effects*
  • Iron Chelating Agents / toxicity*
  • Mutation

Substances

  • Anthraquinones
  • Iron Chelating Agents
  • alizarin
  • DNA