A serotonin-4 receptor-like pseudogene in humans

Brain Res Mol Brain Res. 1998 Jan;53(1-2):98-103. doi: 10.1016/s0169-328x(97)00283-0.

Abstract

During a search for new G-protein-linked receptors for dopamine and serotonin, we found a serotonin-4 receptor-like pseudogene. This receptor-like pseudogene is intronless, contains an in-frame stop codon following transmembrane-3, and has two one-nucleotide insertions between transmembrane-5 and -6 regions which alter the reading frame. The predicted amino acid sequence of the human pseudogene is about 35% identical with that of the rat serotonin-4 receptor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 6*
  • Codon, Terminator
  • DNA Transposable Elements
  • Humans
  • In Situ Hybridization, Fluorescence
  • Introns
  • Karyotyping
  • Leukocytes / metabolism
  • Molecular Sequence Data
  • Pseudogenes*
  • Rats
  • Reading Frames
  • Receptors, Serotonin / biosynthesis
  • Receptors, Serotonin / chemistry
  • Receptors, Serotonin / genetics*
  • Receptors, Serotonin, 5-HT4
  • Restriction Mapping
  • Sequence Alignment
  • Sequence Homology, Amino Acid

Substances

  • Codon, Terminator
  • DNA Transposable Elements
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT4

Associated data

  • GENBANK/U88828