[Neurocysticercosis in children: clinical and radiological analysis and prognostic factors in 54 patients]

Rev Neurol. 1997 Nov;25(147):1681-4.
[Article in Spanish]

Abstract

Introduction and material: We studied 54 patients younger than 17 years of age with neurocysticercosis to determine the clinical manifestations, neuroimaging findings, and prognostic factors of this condition.

Results: Seizures were present in 48 patients, representing the most common clinical manifestation. Forty-eight patients had a normal neurological examination, and only 3 patients had clinical evidence of increased intracranial pressure. CT scan of the brain revealed parenchymal brain cysticerci in 52 patients; one patient had a pure subarachnoid form of the disease and the remaining patient had a mixed (subarachnoid and parenchymal) form. The most common CT finding in patients with parenchymal neurocysticercosis was a single colloidal cyst (19 cases). All patients with seizures were treated with anti-epileptic drugs with an excellent rate of seizure-control. In addition, 23 patients received albendazole that caused resolution of cystic lesions in 19 cases. Anti-epileptic drugs were withdrawn in 13 patients who remained free of seizures during two years. However, 9 (69%) of these patients had recurrent seizures.

Conclusion: This evidence is in contrast with the reported benign course of neurocysticercosis in children, since most patients had seizure relapses despite therapy.

MeSH terms

  • Adolescent
  • Albendazole / therapeutic use
  • Anthelmintics / therapeutic use
  • Anticonvulsants / therapeutic use
  • Brain / diagnostic imaging*
  • Brain Diseases / complications
  • Brain Diseases / diagnostic imaging*
  • Brain Diseases / drug therapy
  • Brain Diseases / parasitology*
  • Carbamazepine / therapeutic use
  • Child
  • Child, Preschool
  • Cysticercosis / complications
  • Cysticercosis / diagnostic imaging*
  • Cysticercosis / drug therapy
  • Epilepsy, Tonic-Clonic / diagnosis
  • Epilepsy, Tonic-Clonic / drug therapy
  • Epilepsy, Tonic-Clonic / etiology
  • Female
  • Humans
  • Male
  • Phenytoin / therapeutic use
  • Prognosis
  • Tomography, X-Ray Computed / methods*

Substances

  • Anthelmintics
  • Anticonvulsants
  • Carbamazepine
  • Phenytoin
  • Albendazole