Correlates of substance abuse disorders in teenagers may suggest new treatment modalities. The present article examines correlates of self-reported substance abuse and dependence among a sample of 1936 youth at high risk for drug abuse, from 21 southern California continuation high schools. Among 32 demographic, drug use, drug use intention, coping, or health attitude-related variables, gender, cigarette smoking, anger coping, depression, and addiction concern were most consistently associated with self-reported substance abuse or substance dependence. These results suggest that affect management may help facilitate the prevention or control of adolescent drug abuse.