Disseminated histoplasmosis presenting with cutaneous lesions in a patient with acquired immunodeficiency syndrome

J Eur Acad Dermatol Venereol. 1998 Mar;10(2):182-5.

Abstract

Objective: Presentation of a case of disseminated histoplasmosis, observed in a non-endemic area, in which cutaneous lesions and fever were the dominant clinical signs of the infection.

Case: A 54-year-old homosexual man with acquired immunodeficiency syndrome (AIDS) related Kaposi's sarcoma presented with cutaneous lesions and fever due to disseminated histoplasmosis. The patient was successfully treated with itraconazole 200 mg/day. He died after 8 months from AIDS dementia complex: disseminated histoplasmosis relapse was not observed.

Conclusion: The case shows that infection with Histoplasma capsulatum must be considered by dermatologists in HIV/AIDS patients, even in non-endemic areas.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / diagnosis*
  • AIDS-Related Opportunistic Infections / drug therapy
  • AIDS-Related Opportunistic Infections / pathology
  • Antifungal Agents / therapeutic use
  • Biopsy, Needle
  • Dermatomycoses / diagnosis*
  • Dermatomycoses / drug therapy
  • Dermatomycoses / pathology
  • Fatal Outcome
  • Histoplasmosis / diagnosis*
  • Histoplasmosis / drug therapy
  • Histoplasmosis / pathology
  • Homosexuality, Male
  • Humans
  • Itraconazole / therapeutic use
  • Male
  • Middle Aged
  • Sarcoma, Kaposi / diagnosis*
  • Sarcoma, Kaposi / pathology
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / pathology

Substances

  • Antifungal Agents
  • Itraconazole