Technical advances and pioneering surgeons have established neuroendoscopy as an accepted diagnostic and therapeutic tool. The clinical indications for endoscopy, variety of operative techniques and number of endoscopic surgeons continue to increase steadily. However, there are fundamental limits to the scope of freehand endoscopy principally governed by the need for direct vision of anatomical and pathological structures. In addition, whilst the expert neuroendoscopist is only occasionally disorientated by complex distorted anatomy, the rising number of novices are likely to be mislead relatively often. We report the integration of neuroendoscopy with an optical neuronavigation system to provide interactive image-guided neuroendoscopy. This combination both removes the constraining requirement for direct vision and provides accurate localisation to guide the surgeon during surgery. We describe the clinical application of this method to two cases where image-guided endoscopy was essential to the safe completion of the procedure.