Abstract
Objective:
This study was performed to test whether corticosteroids were superior to intravenous immunoglobulins (IVIG) in the treatment of neonatal autoimmune thrombocytopenia (NAT).
Methods:
All cases received IVIG, and unresponsive cases received corticosteroids.
Results:
Of 7 babies who received IVIG, only 1 responded. The 6 remaining cases received corticosteroids thereafter, and all of them responded well to this therapy.
Conclusions:
Corticosteroids may be more effective than IVIG in NAT.
MeSH terms
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Adrenal Cortex Hormones / therapeutic use*
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Adult
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Autoimmune Diseases / immunology*
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Cerebral Hemorrhage / prevention & control
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Evaluation Studies as Topic
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Female
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Humans
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Immunity, Maternally-Acquired*
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Immunoglobulin G / immunology
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Immunoglobulins, Intravenous / therapeutic use*
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Immunosuppressive Agents / therapeutic use*
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Infant, Newborn
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Methylprednisolone / therapeutic use
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Platelet Count
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Pregnancy
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Pregnancy Complications, Hematologic / immunology*
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Purpura, Thrombocytopenic, Idiopathic / immunology*
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Thrombocytopenia / congenital
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Thrombocytopenia / etiology
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Thrombocytopenia / therapy*
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Treatment Outcome
Substances
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Adrenal Cortex Hormones
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Immunoglobulin G
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Immunoglobulins, Intravenous
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Immunosuppressive Agents
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Methylprednisolone