Objective: To study the difference of structure and function of HSV-2 gD gene among the wild strain, G and Sav strain. So as to provide theoretical basis for future production of HSV-2 vaccine.
Method: The partial glycoprotein D gene sequence of HSV-2 strain Sav and wild strain isolated from recurred genital herpes simplex were amplified and cloned with PCR.
Results: The homology comparison showed that the homology of DNA and amino acid were 99.2% and 99.1% respectively.
Conclusions: There are high homology of HSV-2 gD gene among the wild strain G and Sav strains, but some variations existed.