Study objective: To establish the source of a community outbreak of Salmonella typhimurium definitive type 124.
Design: Two stage case-control study.
Setting: Three districts in south east Wales.
Subjects: Cases of salmonella food poisoning and community controls.
Main results: An initial case-control study identified an association between illness and eating ham (odds ratio 4.50, 95% confidence intervals 1.10, 21.8) and also found a possible association between illness and food bought from delicatessen stores (odds ratio 5.03, 95% confidence intervals 1.01, 32.3). However, only after a second stage case-control study was a single common ham producer identified as the source (odds ratio 25.0, 95% confidence intervals 2.33, 1155).
Conclusion: Sequential case-control studies are an important and underused tool in the investigation of community outbreaks.