Protection of mice against Plasmodium yoelii sporozoite challenge with P. yoelii merozoite surface protein 1 DNA vaccines

Infect Immun. 1998 Jul;66(7):3457-61. doi: 10.1128/IAI.66.7.3457-3461.1998.

Abstract

Immunization of mice with DNA vaccines encoding the full-length form and C and N termini of Plasmodium yoelii merozoite surface protein 1 provided partial protection against sporozoite challenge and resulted in boosting of antibody titers after challenge. In C57BL/6 mice, two DNA vaccines provided protection comparable to that of recombinant protein consisting of the C terminus in Freund's adjuvant.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antigens, Protozoan / genetics*
  • Female
  • Immunization
  • Malaria Vaccines / immunology*
  • Merozoite Surface Protein 1
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Plasmodium yoelii / immunology*
  • Protein Precursors / immunology*
  • Protozoan Proteins / immunology*
  • Vaccines, DNA / immunology*
  • Vaccines, Synthetic / immunology

Substances

  • Antigens, Protozoan
  • Malaria Vaccines
  • Merozoite Surface Protein 1
  • Protein Precursors
  • Protozoan Proteins
  • Vaccines, DNA
  • Vaccines, Synthetic