A 27-year-old right-handed woman was operated with resection of an epileptogenic lesion, a nonmalignant tumor, in the left frontal lobe. The surrounding cortical and subcortical tissue in the tumor-containing gyrus was also resected. Care was taken during the operation not to interfere with motor or language related cortical areas. Pre- and postoperatively, she was tested with a dichotic memory test. In the preoperative test, she showed a marked Left Ear Advantage. In the corresponding tests on the second and fourth postoperative days and at follow-up, her performance had changed to a Right Ear Advantage. A possible explanation of this result is that neighboring cortical areas involved in hemispheric specialization for lateralized, verbal cognitive functions are suppressed by a focal epiletogeneic activity caused by the tumor. The subsequent removal of this influence allowed these cortical areas to function normally.