Theonellapeptolide IIIe, a new cyclic peptolide from the New Zealand deep water sponge, Lamellomorpha strongylata

S Li; E J Dumdei; J W Blunt; M H Munro; W T Robinson; L K Pannell

doi:10.1021/np970417r

Theonellapeptolide IIIe, a new cyclic peptolide from the New Zealand deep water sponge, Lamellomorpha strongylata

J Nat Prod. 1998 Jun 26;61(6):724-8. doi: 10.1021/np970417r.

Authors

S Li¹, E J Dumdei, J W Blunt, M H Munro, W T Robinson, L K Pannell

Affiliation

¹ Department of Chemistry, University of Canterbury, Christchurch, New Zealand.

PMID: 9644054
DOI: 10.1021/np970417r

Abstract

The structure, stereochemistry, and conformation of theonellapeptolide IIIe (1), a new 36-membered ring cyclic peptolide from the New Zealand deep-water sponge Lamellomorpha strongylata, is described. The sequence of the cytotoxic peptolide was determined through a combination of NMR and MS-MS techniques and confirmed by X-ray crystal structure analysis, which, with chiral HPLC, established the absolute stereochemistry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / analysis
Animals
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Gas Chromatography-Mass Spectrometry
New Zealand
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology
Porifera / chemistry*
Protein Conformation
Spectrometry, Mass, Fast Atom Bombardment
X-Ray Diffraction

Substances

Amino Acids
Antineoplastic Agents
Peptides, Cyclic
theonellapeptolide IIIe