Molecular cloning and characterisation of a mouse gene encoding an isoform of the neuronal cyclin-dependent kinase 5 (CDK5) activator

Biochim Biophys Acta. 1998 Jul 9;1398(3):371-6. doi: 10.1016/s0167-4781(98)00073-6.

Abstract

We have isolated and characterised the mouse gene for the p39 activator, designated p39is, which encodes a protein of 369 amino acids. The mouse p39 protein exhibits 95% amino acid identity to a previously characterised human p39 cDNA and the novel gene sequence corresponds to a single genomic locus in mouse. The p39is mRNA is highly expressed in the mouse central nervous system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • Cyclin-Dependent Kinase 5
  • Cyclin-Dependent Kinases*
  • DNA, Complementary
  • Enzyme Activation
  • Humans
  • Mice
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics*
  • Neurons / metabolism*
  • Protein Serine-Threonine Kinases / metabolism*
  • Sequence Homology, Amino Acid

Substances

  • Cdk5 activator p39
  • DNA, Complementary
  • Nerve Tissue Proteins
  • Cyclin-Dependent Kinase 5
  • Protein Serine-Threonine Kinases
  • CDK5 protein, human
  • Cdk5 protein, mouse
  • Cyclin-Dependent Kinases

Associated data

  • GENBANK/U90267