Maternal and viral factors in vertical transmission of HIV-1 subtype E

Southeast Asian J Trop Med Public Health. 1997 Dec;28(4):689-98.

Abstract

Vertical transmission of HIV-1 is caused by multifactorial factors. To access the relationship of viral factors involving in perinatal transmission of HIV-1 subtype E, which is the predominant type in Thailand, plasma viral load, blood CD4+ lymphocyte level, heteroduplex mobility, and V3 sequence of the HIV-1 envelope gene were studied in 32 transmitting and 25 non-transmitting mothers. We found that HIV-1 subtype E vertical transmission was strongly associated with high maternal plasma viral RNA (> 4 x 10(4) copies/ml) and high genetic diversity of envelope gene determined by heteroduplex mobility (< 0.9). The variation of nucleotide sequences in envelope gene of subtype E vertical transmission could not determine in V3 region. Hence, plasma viral load and heteroduplex mobility can be used as prediction factors in vertical transmission of HIV-1 subtype E.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Amino Acid Sequence
  • DNA Primers
  • Female
  • HIV Infections / transmission*
  • HIV Infections / virology*
  • HIV-1 / isolation & purification*
  • Humans
  • Infant
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical*
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Pregnancy
  • RNA, Viral / blood
  • Thailand
  • Viral Load

Substances

  • DNA Primers
  • RNA, Viral