Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part I: Dioxygenated 4-methyl coumarins as superb antioxidant and radical scavenging agents

H G Raj; V S Parmar; S C Jain; S Goel; Poonam; Himanshu; S Malhotra; A Singh; C E Olsen; J Wengel

doi:10.1016/s0968-0896(98)00043-1

Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part I: Dioxygenated 4-methyl coumarins as superb antioxidant and radical scavenging agents

Bioorg Med Chem. 1998 Jun;6(6):833-9. doi: 10.1016/s0968-0896(98)00043-1.

Authors

H G Raj¹, V S Parmar, S C Jain, S Goel, Poonam, Himanshu, S Malhotra, A Singh, C E Olsen, J Wengel

Affiliation

¹ Department of Biochemistry, V.P. Chest Institute, University of Delhi, India.

PMID: 9681149
DOI: 10.1016/s0968-0896(98)00043-1

Abstract

Twenty-three 4-methylcoumarins bearing different functionalities have been examined for the first time for their effect on NADPH-catalysed liver-microsomal lipid peroxidation with a view to establish structure-activity relationship. Dihydroxy- and diacetoxy-4-methylcoumarins produced dramatic inhibition of lipid peroxidation. 7,8-Diacetoxy-4-methylcoumarin and 7,8-dihydroxy-4-methylcoumarin were found to possess superb antioxidant and radical scavenging activities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antioxidants / chemistry
Antioxidants / pharmacology*
Coumarins / chemistry
Coumarins / pharmacology*
Free Radical Scavengers / chemistry
Free Radical Scavengers / pharmacology*
In Vitro Techniques
Lipid Peroxidation / drug effects
Microsomes, Liver / drug effects
Microsomes, Liver / metabolism
Rats
Structure-Activity Relationship
Vitamin E / pharmacology

Substances

7,8-diacetoxy-4-methylcoumarin
7,8-dihydroxy-4-methylcoumarin
Antioxidants
Coumarins
Free Radical Scavengers
Vitamin E