A lasting change in trazodone response after non-convulsive electroshock therapy for medication-resistant senile depression

Psychiatry Clin Neurosci. 1998 Feb;52(1):111-3. doi: 10.1111/j.1440-1819.1998.tb00982.x.

Abstract

A senile patient showed a dramatic recovery from medication-resistant depression after non-convulsive electroshock therapy (nc-EST), with a lasting change in response to trazodone, which mainly acts as a serotonin re-uptake inhibitor. This result suggests that a change in the serotonin reuptake mechanism may be involved in the effect of nc-EST on depression.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antidepressive Agents, Second-Generation / administration & dosage*
  • Antidepressive Agents, Second-Generation / adverse effects
  • Combined Modality Therapy
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / drug therapy*
  • Depressive Disorder, Major / pathology
  • Electroconvulsive Therapy*
  • Frontal Lobe / blood supply
  • Humans
  • Male
  • Regional Blood Flow / drug effects
  • Tomography, Emission-Computed, Single-Photon
  • Trazodone / administration & dosage*
  • Trazodone / adverse effects
  • Treatment Outcome

Substances

  • Antidepressive Agents, Second-Generation
  • Trazodone