Fluorescence in situ hybridization characterization of the chromosomal breakpoints in a case with ins(17;3)(q11.2;q21q26.3) and acute monocytic leukemia

S Schnittger; E Joachimmayer; C Schoch; R Fuchs; C Fonatsch

doi:10.1016/s0165-4608(98)00071-5

Fluorescence in situ hybridization characterization of the chromosomal breakpoints in a case with ins(17;3)(q11.2;q21q26.3) and acute monocytic leukemia

Cancer Genet Cytogenet. 1998 Oct 15;106(2):122-7. doi: 10.1016/s0165-4608(98)00071-5.

Authors

S Schnittger¹, E Joachimmayer, C Schoch, R Fuchs, C Fonatsch

Affiliation

¹ AG Tumorcytogenetik, Institut für Humangenetik der Medizinischen Universität zu Lübeck, Germany.

PMID: 9797776
DOI: 10.1016/s0165-4608(98)00071-5

Abstract

A 63-year-old patient with acute myeloid leukemia of FAB M5 subtype revealing chromosomal breakpoints in 3q21 and 3q26 is presented. Although rearrangements of 3q21 and 3q26 are relatively common in patients with myelocytic malignancies, this is the first report of ins(17;3)(q11.2;q21q26.3). We defined the chromosomal breakpoints and the extent of the insertion by fluorescence in situ hybridization (FISH) with yeast artificial chromosomes (YACs).

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Aberrations*
Chromosome Breakage*
Chromosomes, Human, Pair 17*
Chromosomes, Human, Pair 3*
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Monocytic, Acute / genetics*
Middle Aged
Reverse Transcriptase Polymerase Chain Reaction