Expression of the AMPA-type glutamate receptor subunits in the chick optic tectum changes biphasically after retinal deafferentation

Brain Res. 1998 Nov 9;810(1-2):283-7. doi: 10.1016/s0006-8993(98)00937-8.

Abstract

Effects of retinal lesions on the expression of AMPA-type glutamate receptor (GluR) subunits in the chick optic tectum were evaluated with immunohistochemistry and immunoblotting. Expression of GluR1 and GluR2/3 subunits decreased in the deafferented tectum after 2 days and increased after 7 days postlesion. These results suggest biphasic effects of retinal lesions upon the expression of GluR subunits, possibly due to removal of the glutamatergic input from the retina.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Survival / physiology
  • Chickens / physiology*
  • Denervation
  • Histocytochemistry
  • Image Processing, Computer-Assisted
  • Neurons, Afferent / physiology*
  • Receptors, AMPA / biosynthesis*
  • Retina / physiology*
  • Superior Colliculi / metabolism*

Substances

  • Receptors, AMPA