Psychotic symptoms in dementia associated with motor neuron disease: a pathophysiological hypothesis

J Neuropsychiatry Clin Neurosci. 1998 Fall;10(4):456-8. doi: 10.1176/jnp.10.4.456.

Abstract

Three patients with neuropathologically confirmed frontotemporal dementia, motor neuron disease type, manifested hallucinations. In this dementia, the superficial layers of the frontal and temporal cortices are predominantly affected. Hallucinations may emerge as release phenomena secondary to selective laminar cortical involvement.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Dementia / complications
  • Dementia / physiopathology*
  • Dementia / psychology*
  • Electromyography
  • Fatal Outcome
  • Female
  • Frontal Lobe / physiopathology
  • Hallucinations / psychology
  • Humans
  • Male
  • Middle Aged
  • Motor Neuron Disease / complications
  • Motor Neuron Disease / physiopathology*
  • Motor Neuron Disease / psychology*
  • Temporal Lobe / physiopathology