Muscle development: electrical control of gene expression

Curr Biol. 1998 Dec 3;8(24):R892-4. doi: 10.1016/s0960-9822(07)00554-4.

Abstract

The electrical activity resulting from stimulation by motor neurons regulates gene expression in skeletal muscle fibres. A recent study has suggested a mechanism by which distinct patterns of electrical stimulus might be integrated to control the contractile properties of these fibres.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcineurin / physiology
  • DNA-Binding Proteins / physiology
  • Electrophysiology
  • Gene Expression Regulation
  • Humans
  • Motor Neurons / physiology
  • Muscle Contraction / genetics
  • Muscle Contraction / physiology
  • Muscle Development*
  • Muscle Fibers, Fast-Twitch / physiology
  • Muscle Fibers, Slow-Twitch / physiology
  • Muscle, Skeletal / growth & development*
  • Muscle, Skeletal / innervation*
  • Muscle, Skeletal / physiology
  • NFATC Transcription Factors
  • Nuclear Proteins*
  • Transcription Factors / physiology

Substances

  • DNA-Binding Proteins
  • NFATC Transcription Factors
  • Nuclear Proteins
  • Transcription Factors
  • Calcineurin