A profile of health research in Jamaica between 1991 and 1995 was prepared in order to examine research capacity and needs as part of the process of promoting essential national health research. Of 43 organisations and research groups surveyed, 29 met the criterion of at least one peer reviewed publication between 1991 and 1995, and there were 201 health researchers. Most of the research groups had fewer than 20 professional staff with less than 10 engaged in health research. Institutional objectives and funding opportunities largely determined research priorities. 704 research papers were published over the period with 10 of the organisations responsible for 469 (66.6%). The number of research papers is overestimated because the same paper may be reported by more than one research group due to multiple authorship. On the whole, local research groups appear to be small, vulnerable, under-funded and deficient in basic equipment as well as trained and experienced researchers and support staff. These are compelling reasons for health researchers to come together to tackle common problems, promote collaboration and forge a joint strategy to strengthen health research capability in Jamaica.