Inhibitors of the bacterial cell wall biosynthesis enzyme MurD

L D Gegnas; S T Waddell; R M Chabin; S Reddy; K K Wong

doi:10.1016/s0960-894x(98)00285-6

Inhibitors of the bacterial cell wall biosynthesis enzyme MurD

Bioorg Med Chem Lett. 1998 Jul 7;8(13):1643-8. doi: 10.1016/s0960-894x(98)00285-6.

Authors

L D Gegnas¹, S T Waddell, R M Chabin, S Reddy, K K Wong

Affiliation

¹ Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.

PMID: 9873406
DOI: 10.1016/s0960-894x(98)00285-6

Abstract

A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.

MeSH terms

Cell Wall / enzymology*
Escherichia coli / enzymology*
Molecular Structure
Organophosphorus Compounds / chemistry
Peptide Synthases / antagonists & inhibitors*
Peptide Synthases / chemistry

Substances

Organophosphorus Compounds
Peptide Synthases
UDP-N-acetylmuramoylalanine-D-glutamate ligase