TRAIL induces apoptosis and activation of NFkappaB

Eur Cytokine Netw. 1998 Dec;9(4):687-8.

Abstract

TRAIL (TNF-related-apoptosis-inducing-ligand) was found as a new member of the TNF family which mediates cell death in a wide variety of malignant cell lines and primary tumor cells. TRAIL induces two different signals, cell death mediated by caspases and gene induction mediated by NFkappaB. Inhibition of TRAIL-induced activation of NFkappaB augments apoptosis induction by TRAIL and attenuates apoptosis resistance.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / drug effects*
  • Apoptosis / physiology
  • Apoptosis Regulatory Proteins
  • Gene Expression Regulation / drug effects
  • Humans
  • Membrane Glycoproteins / pharmacology*
  • Membrane Glycoproteins / physiology
  • NF-kappa B / metabolism*
  • Receptors, Tumor Necrosis Factor / physiology
  • Signal Transduction
  • TNF-Related Apoptosis-Inducing Ligand
  • Transcriptional Activation
  • Tumor Necrosis Factor-alpha / pharmacology*
  • Tumor Necrosis Factor-alpha / physiology

Substances

  • Apoptosis Regulatory Proteins
  • Membrane Glycoproteins
  • NF-kappa B
  • Receptors, Tumor Necrosis Factor
  • TNF-Related Apoptosis-Inducing Ligand
  • TNFSF10 protein, human
  • Tumor Necrosis Factor-alpha