Abstract
Day-night differences of trigeminal chemosensitivity were investigated in 18 healthy volunteers employing both pain-related cortical potentials and pain ratings in response to stimulation of the nasal mucosa with CO2. Day-night differences were found with N 1 P2 amplitudes, P2 latencies and pain ratings. It is concluded that the time of the day must not be ignored when human chemosensitivity is investigated at suprathreshold levels.
Publication types
-
Clinical Trial
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Carbon Dioxide
-
Circadian Rhythm / physiology*
-
Electroencephalography
-
Evoked Potentials, Somatosensory / physiology
-
Female
-
Humans
-
Male
-
Mathematical Computing
-
Multivariate Analysis
-
Nociceptors / drug effects
-
Pain / chemically induced
-
Pain / physiopathology*
-
Reference Values
-
Sensory Thresholds / physiology
-
Stimulation, Chemical
-
Trigeminal Nerve / physiology*