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Page 1
Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines.
Arvanitis AG, Gilligan PJ, Chorvat RJ, Cheeseman RS, Christos TE, Bakthavatchalam R, Beck JP, Cocuzza AJ, Hobbs FW, Wilde RG, Arnold C, Chidester D, Curry M, He L, Hollis A, Klaczkiewicz J, Krenitsky PJ, Rescinito JP, Scholfield E, Culp S, De Souza EB, Fitzgerald L, Grigoriadis D, Tam SW, Shen HL, et al. Arvanitis AG, et al. Among authors: wilde rg. J Med Chem. 1999 Mar 11;42(5):805-18. doi: 10.1021/jm980222w. J Med Chem. 1999. PMID: 10072679
Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands.
Arvanitis AG, Rescinito JT, Arnold CR, Wilde RG, Cain GA, Sun JH, Yan JS, Teleha CA, Fitzgerald LW, McElroy J, Zaczek R, Hartig PR, Grossman S, Arneric SP, Gilligan PJ, Olson RE, Robertson DW. Arvanitis AG, et al. Among authors: wilde rg. Bioorg Med Chem Lett. 2003 Jan 6;13(1):125-8. doi: 10.1016/s0960-894x(02)00833-8. Bioorg Med Chem Lett. 2003. PMID: 12467631
Imidazo[4,5-c]pyridines as corticotropin releasing factor receptor ligands.
Arvanitis AG, Rescinito JT, Arnold CR, Wilde RG, Fitzgerald LW, Zaczek R, Hartig PR, Grossman S, Arneric SP, Gilligan PJ, Olson RE, Robertson DW. Arvanitis AG, et al. Among authors: wilde rg. Bioorg Med Chem Lett. 2003 Jan 6;13(1):129-31. doi: 10.1016/s0960-894x(02)00834-x. Bioorg Med Chem Lett. 2003. PMID: 12467632
Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines.
Chorvat RJ, Bakthavatchalam R, Beck JP, Gilligan PJ, Wilde RG, Cocuzza AJ, Hobbs FW, Cheeseman RS, Curry M, Rescinito JP, Krenitsky P, Chidester D, Yarem JA, Klaczkiewicz JD, Hodge CN, Aldrich PE, Wasserman ZR, Fernandez CH, Zaczek R, Fitzgerald LW, Huang SM, Shen HL, Wong YN, Chien BM, Arvanitis A, et al. Chorvat RJ, et al. Among authors: wilde rg. J Med Chem. 1999 Mar 11;42(5):833-48. doi: 10.1021/jm980224g. J Med Chem. 1999. PMID: 10072681
Dihydropyridopyrazinones and dihydropteridinones as corticotropin-releasing factor-1 receptor antagonists: structure-activity relationships and computational modeling.
Dzierba CD, Tebben AJ, Wilde RG, Takvorian AG, Rafalski M, Kasireddy-Polam P, Klaczkiewicz JD, Pechulis AD, Davis AL, Sweet MP, Woo AM, Yang Z, Ebeltoft SM, Molski TF, Zhang G, Zaczek RC, Trainor GL, Combs AP, Gilligan PJ. Dzierba CD, et al. Among authors: wilde rg. J Med Chem. 2007 May 3;50(9):2269-72. doi: 10.1021/jm0611410. Epub 2007 Apr 3. J Med Chem. 2007. PMID: 17402721
ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes.
Wilde RG, Billheimer JT, Germain SJ, Hausner EA, Meunier PC, Munzer DA, Stoltenborg JK, Gillies PJ, Burcham DL, Huang SM, Klaczkiewicz JD, Ko SS, Wexler RR. Wilde RG, et al. Bioorg Med Chem. 1996 Sep;4(9):1493-513. doi: 10.1016/0968-0896(96)00143-5. Bioorg Med Chem. 1996. PMID: 8894107
PTC124 targets genetic disorders caused by nonsense mutations.
Welch EM, Barton ER, Zhuo J, Tomizawa Y, Friesen WJ, Trifillis P, Paushkin S, Patel M, Trotta CR, Hwang S, Wilde RG, Karp G, Takasugi J, Chen G, Jones S, Ren H, Moon YC, Corson D, Turpoff AA, Campbell JA, Conn MM, Khan A, Almstead NG, Hedrick J, Mollin A, Risher N, Weetall M, Yeh S, Branstrom AA, Colacino JM, Babiak J, Ju WD, Hirawat S, Northcutt VJ, Miller LL, Spatrick P, He F, Kawana M, Feng H, Jacobson A, Peltz SW, Sweeney HL. Welch EM, et al. Among authors: wilde rg. Nature. 2007 May 3;447(7140):87-91. doi: 10.1038/nature05756. Epub 2007 Apr 22. Nature. 2007. PMID: 17450125
12 results