Tharnish P - Search Results

1

Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.

Shi J, McAtee JJ, Schlueter Wirtz S, Tharnish P, Juodawlkis A, Liotta DC, Schinazi RF. Shi J, et al. Among authors: tharnish p. J Med Chem. 1999 Mar 11;42(5):859-67. doi: 10.1021/jm980510s. J Med Chem. 1999. PMID: 10072683

2

Synthesis and evaluation of novel potent HCV NS5A inhibitors.

Zhang H, Zhou L, Amblard F, Shi J, Bobeck DR, Tao S, McBrayer TR, Tharnish PM, Whitaker T, Coats SJ, Schinazi RF. Zhang H, et al. Among authors: tharnish pm. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4864-8. doi: 10.1016/j.bmcl.2012.05.039. Epub 2012 May 24. Bioorg Med Chem Lett. 2012. PMID: 22704887 Free PMC article.

3

Enantioselective synthesis and biological evaluation of 5-o-carboranyl pyrimidine nucleosides.

Mourier NS, Eleuteri A, Hurwitz SJ, Tharnish PM, Schinazi RF. Mourier NS, et al. Among authors: tharnish pm. Bioorg Med Chem. 1999 Dec;7(12):2759-66. doi: 10.1016/s0968-0896(99)00222-9. Bioorg Med Chem. 1999. PMID: 10658581

4

Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues.

Stuyver LJ, Lostia S, Adams M, Mathew JS, Pai BS, Grier J, Tharnish PM, Choi Y, Chong Y, Choo H, Chu CK, Otto MJ, Schinazi RF. Stuyver LJ, et al. Antimicrob Agents Chemother. 2002 Dec;46(12):3854-60. doi: 10.1128/AAC.46.12.3854-3860.2002. Antimicrob Agents Chemother. 2002. PMID: 12435688 Free PMC article.

5

N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity.

Shi J, Mathew JS, Tharnish PM, Rachakonda S, Pai SB, Adams M, Grier JP, Gallagher K, Zhang H, Wu JT, Shi G, Geleziunas R, Erickson-Viitanen S, Stuyver L, Otto MJ, Watanabe KA, Schinazi RF. Shi J, et al. Among authors: tharnish pm. Antivir Chem Chemother. 2003 Mar;14(2):81-90. doi: 10.1177/095632020301400203. Antivir Chem Chemother. 2003. PMID: 12856919 Free article.

6

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.

Wang P, Hollecker L, Pankiewicz KW, Patterson SE, Whitaker T, McBrayer TR, Tharnish PM, Sidwell RW, Stuyver LJ, Otto MJ, Schinazi RF, Watanabe KA. Wang P, et al. Among authors: tharnish pm. J Med Chem. 2004 Nov 18;47(24):6100-3. doi: 10.1021/jm0401210. J Med Chem. 2004. PMID: 15537363

7

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

Clark JL, Hollecker L, Mason JC, Stuyver LJ, Tharnish PM, Lostia S, McBrayer TR, Schinazi RF, Watanabe KA, Otto MJ, Furman PA, Stec WJ, Patterson SE, Pankiewicz KW. Clark JL, et al. J Med Chem. 2005 Aug 25;48(17):5504-8. doi: 10.1021/jm0502788. J Med Chem. 2005. PMID: 16107149

8

Synthesis and structure-activity relationships of novel anti-hepatitis C agents: N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one derivatives.

Wang P, Du J, Rachakonda S, Chun BK, Tharnish PM, Stuyver LJ, Otto MJ, Schinazi RF, Watanabe KA. Wang P, et al. Among authors: tharnish pm. J Med Chem. 2005 Oct 6;48(20):6454-60. doi: 10.1021/jm058223t. J Med Chem. 2005. PMID: 16190771

9

Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.

Rondla R, Coats SJ, McBrayer TR, Grier J, Johns M, Tharnish PM, Whitaker T, Zhou L, Schinazi RF. Rondla R, et al. Among authors: tharnish pm. Antivir Chem Chemother. 2009 Oct 19;20(2):99-106. doi: 10.3851/IMP1400. Antivir Chem Chemother. 2009. PMID: 19843980 Free PMC article.

10

Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.

Zhang HW, Zhou L, Coats SJ, McBrayer TR, Tharnish PM, Bondada L, Detorio M, Amichai SA, Johns MD, Whitaker T, Schinazi RF. Zhang HW, et al. Among authors: tharnish pm. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6788-92. doi: 10.1016/j.bmcl.2011.09.034. Epub 2011 Sep 20. Bioorg Med Chem Lett. 2011. PMID: 21983447 Free PMC article.

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