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Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.
van der Horst GT, Muijtjens M, Kobayashi K, Takano R, Kanno S, Takao M, de Wit J, Verkerk A, Eker AP, van Leenen D, Buijs R, Bootsma D, Hoeijmakers JH, Yasui A. van der Horst GT, et al. Among authors: van leenen d. Nature. 1999 Apr 15;398(6728):627-30. doi: 10.1038/19323. Nature. 1999. PMID: 10217146
Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60.
Gao Y, Koppen A, Rakhshandehroo M, Tasdelen I, van de Graaf SF, van Loosdregt J, van Beekum O, Hamers N, van Leenen D, Berkers CR, Berger R, Holstege FC, Coffer PJ, Brenkman AB, Ovaa H, Kalkhoven E. Gao Y, et al. Among authors: van loosdregt j, van de graaf sf, van leenen d, van beekum o. Nat Commun. 2013;4:2656. doi: 10.1038/ncomms3656. Nat Commun. 2013. PMID: 24141283 Free article.
Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity.
Dansen TB, Smits LM, van Triest MH, de Keizer PL, van Leenen D, Koerkamp MG, Szypowska A, Meppelink A, Brenkman AB, Yodoi J, Holstege FC, Burgering BM. Dansen TB, et al. Among authors: van triest mh, van leenen d. Nat Chem Biol. 2009 Sep;5(9):664-72. doi: 10.1038/nchembio.194. Epub 2009 Aug 2. Nat Chem Biol. 2009. PMID: 19648934
Twenty-two novel mutations in the lysosomal alpha-glucosidase gene (GAA) underscore the genotype-phenotype correlation in glycogen storage disease type II.
Hermans MM, van Leenen D, Kroos MA, Beesley CE, Van Der Ploeg AT, Sakuraba H, Wevers R, Kleijer W, Michelakakis H, Kirk EP, Fletcher J, Bosshard N, Basel-Vanagaite L, Besley G, Reuser AJ. Hermans MM, et al. Among authors: van der ploeg at, van leenen d. Hum Mutat. 2004 Jan;23(1):47-56. doi: 10.1002/humu.10286. Hum Mutat. 2004. PMID: 14695532
FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1).
Kloet DE, Polderman PE, Eijkelenboom A, Smits LM, van Triest MH, van den Berg MC, Groot Koerkamp MJ, van Leenen D, Lijnzaad P, Holstege FC, Burgering BM. Kloet DE, et al. Among authors: van leenen d. Biochem J. 2015 Jul 15;469(2):289-98. doi: 10.1042/BJ20140831. Epub 2015 May 20. Biochem J. 2015. PMID: 25990325 Free PMC article.
FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression.
Hornsveld M, Smits LMM, Meerlo M, van Amersfoort M, Groot Koerkamp MJA, van Leenen D, Kloet DEA, Holstege FCP, Derksen PWB, Burgering BMT, Dansen TB. Hornsveld M, et al. Among authors: van leenen d. Cancer Res. 2018 May 1;78(9):2356-2369. doi: 10.1158/0008-5472.CAN-17-2511. Epub 2018 Feb 12. Cancer Res. 2018. PMID: 29440168
47 results