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Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation.
Pieples K, Arteaga G, Solaro RJ, Grupp I, Lorenz JN, Boivin GP, Jagatheesan G, Labitzke E, DeTombe PP, Konhilas JP, Irving TC, Wieczorek DF. Pieples K, et al. Among authors: wieczorek df. Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1344-53. doi: 10.1152/ajpheart.00351.2002. Epub 2002 Jun 13. Am J Physiol Heart Circ Physiol. 2002. PMID: 12234784 Free article.
Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis.
Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Arteaga GM, Solaro RJ, Liggett SB, Wieczorek DF. Jagatheesan G, et al. Among authors: wieczorek df. Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H949-58. doi: 10.1152/ajpheart.01341.2006. Epub 2007 Apr 6. Am J Physiol Heart Circ Physiol. 2007. PMID: 17416600 Free article.
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity.
Rajan S, Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, Urboniene D, Arteaga GM, Wolska BM, Solaro RJ, Liggett SB, Wieczorek DF. Rajan S, et al. Among authors: wieczorek df. Circ Res. 2007 Jul 20;101(2):205-14. doi: 10.1161/CIRCRESAHA.107.148379. Epub 2007 Jun 7. Circ Res. 2007. PMID: 17556658
Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform.
Rajan S, Jagatheesan G, Karam CN, Alves ML, Bodi I, Schwartz A, Bulcao CF, D'Souza KM, Akhter SA, Boivin GP, Dube DK, Petrashevskaya N, Herr AB, Hullin R, Liggett SB, Wolska BM, Solaro RJ, Wieczorek DF. Rajan S, et al. Among authors: wieczorek df. Circulation. 2010 Jan 26;121(3):410-8. doi: 10.1161/CIRCULATIONAHA.109.889725. Epub 2010 Jan 11. Circulation. 2010. PMID: 20065163 Free PMC article.
Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins.
Alves ML, Dias FAL, Gaffin RD, Simon JN, Montminy EM, Biesiadecki BJ, Hinken AC, Warren CM, Utter MS, Davis RT Rd, Sakthivel S, Robbins J, Wieczorek DF, Solaro RJ, Wolska BM. Alves ML, et al. Among authors: wieczorek df. Circ Cardiovasc Genet. 2014 Apr;7(2):132-143. doi: 10.1161/CIRCGENETICS.113.000324. Epub 2014 Feb 28. Circ Cardiovasc Genet. 2014. PMID: 24585742 Free PMC article.
70 results