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Page 1
Design of potent and selective GPR119 agonists for type II diabetes.
Szewczyk JW, Acton J, Adams AD, Chicchi G, Freeman S, Howard AD, Huang Y, Li C, Meinke PT, Mosely R, Murphy E, Samuel R, Santini C, Yang M, Zhang Y, Zhao K, Wood HB. Szewczyk JW, et al. Among authors: adams ad. Bioorg Med Chem Lett. 2011 May 1;21(9):2665-9. doi: 10.1016/j.bmcl.2010.12.086. Epub 2010 Dec 22. Bioorg Med Chem Lett. 2011. PMID: 21273063
O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.
Adams AD, Hu Z, von Langen D, Dadiz A, Elbrecht A, MacNaul KL, Berger JP, Zhou G, Doebber TW, Meurer R, Forrest MJ, Moller DE, Jones AB. Adams AD, et al. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3185-90. doi: 10.1016/s0960-894x(03)00702-9. Bioorg Med Chem Lett. 2003. PMID: 12951090
A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux.
Sparrow CP, Baffic J, Lam MH, Lund EG, Adams AD, Fu X, Hayes N, Jones AB, Macnaul KL, Ondeyka J, Singh S, Wang J, Zhou G, Moller DE, Wright SD, Menke JG. Sparrow CP, et al. Among authors: adams ad. J Biol Chem. 2002 Mar 22;277(12):10021-7. doi: 10.1074/jbc.M108225200. Epub 2002 Jan 14. J Biol Chem. 2002. PMID: 11790770 Free article.
SAR studies: designing potent and selective LXR agonists.
Szewczyk JW, Huang S, Chin J, Tian J, Mitnaul L, Rosa RL, Peterson L, Sparrow CP, Adams AD. Szewczyk JW, et al. Among authors: adams ad. Bioorg Med Chem Lett. 2006 Jun 1;16(11):3055-60. doi: 10.1016/j.bmcl.2006.02.050. Epub 2006 Mar 10. Bioorg Med Chem Lett. 2006. PMID: 16529931
Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype.
Lund EG, Peterson LB, Adams AD, Lam MH, Burton CA, Chin J, Guo Q, Huang S, Latham M, Lopez JC, Menke JG, Milot DP, Mitnaul LJ, Rex-Rabe SE, Rosa RL, Tian JY, Wright SD, Sparrow CP. Lund EG, et al. Among authors: adams ad. Biochem Pharmacol. 2006 Feb 14;71(4):453-63. doi: 10.1016/j.bcp.2005.11.004. Epub 2005 Dec 2. Biochem Pharmacol. 2006. PMID: 16325781
62 results