Douglas KT - Search Results

1

Rational drug design using trypanothione reductase as a target for anti-trypanosomal and anti-leishmanial drug leads.

Austin SE, Khan MO, Douglas KT. Austin SE, et al. Among authors: douglas kt. Drug Des Discov. 1999 Jul;16(1):5-23. Drug Des Discov. 1999. PMID: 10466053 Review.

2

Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines.

Khan MO, Austin SE, Chan C, Yin H, Marks D, Vaghjiani SN, Kendrick H, Yardley V, Croft SL, Douglas KT. Khan MO, et al. Among authors: douglas kt. J Med Chem. 2000 Aug 10;43(16):3148-56. doi: 10.1021/jm000156+. J Med Chem. 2000. PMID: 10956223

3

Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide.

Parveen S, Khan MO, Austin SE, Croft SL, Yardley V, Rock P, Douglas KT. Parveen S, et al. Among authors: douglas kt. J Med Chem. 2005 Dec 15;48(25):8087-97. doi: 10.1021/jm050819t. J Med Chem. 2005. PMID: 16335933

4

Specific peptide inhibitors of trypanothione reductase with backbone structures unrelated to that of substrate: potential rational drug design lead frameworks.

McKie JH, Garforth J, Jaouhari R, Chan C, Yin H, Besheya T, Fairlamb AH, Douglas KT. McKie JH, et al. Among authors: douglas kt. Amino Acids. 2001;20(2):145-53. doi: 10.1007/s007260170055. Amino Acids. 2001. PMID: 11332449

5

Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine.

Garforth J, Yin H, McKie JH, Douglas KT, Fairlamb AH. Garforth J, et al. Among authors: douglas kt. J Enzyme Inhib. 1997 Aug;12(3):161-73. doi: 10.3109/14756369709029312. J Enzyme Inhib. 1997. PMID: 9314113

6

Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures.

Benson TJ, McKie JH, Garforth J, Borges A, Fairlamb AH, Douglas KT. Benson TJ, et al. Among authors: douglas kt. Biochem J. 1992 Aug 15;286 ( Pt 1)(Pt 1):9-11. doi: 10.1042/bj2860009. Biochem J. 1992. PMID: 1355650 Free PMC article.

7

Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.

Chan C, Yin H, Garforth J, McKie JH, Jaouhari R, Speers P, Douglas KT, Rock PJ, Yardley V, Croft SL, Fairlamb AH. Chan C, et al. Among authors: douglas kt. J Med Chem. 1998 Jan 15;41(2):148-56. doi: 10.1021/jm960814j. J Med Chem. 1998. PMID: 9457238

8

Cole C, Marks DS, Jaffar M, Stratford IJ, Douglas KT, Freeman S. Cole C, et al. Among authors: douglas kt. Anticancer Drug Des. 1999 Oct;14(5):411-20. Anticancer Drug Des. 1999. PMID: 10766296

9

Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead.

Chan C, Yin H, McKie JH, Fairlamb AH, Douglas KT. Chan C, et al. Among authors: douglas kt. Amino Acids. 2002 Jun;22(4):297-308. doi: 10.1007/s007260200016. Amino Acids. 2002. PMID: 12107758

10

Synthesis of substrate analogues for trypanothione reductase.

el-Waer AF, Benson T, Douglas KT. el-Waer AF, et al. Among authors: douglas kt. Int J Pept Protein Res. 1993 Feb;41(2):141-6. doi: 10.1111/j.1399-3011.1993.tb00124.x. Int J Pept Protein Res. 1993. PMID: 8458687

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

147 results

Search Page

Filters