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Page 1
Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70.
Vu CB, Corpuz EG, Merry TJ, Pradeepan SG, Bartlett C, Bohacek RS, Botfield MC, Eyermann CJ, Lynch BA, MacNeil IA, Ram MK, van Schravendijk MR, Violette S, Sawyer TK. Vu CB, et al. Among authors: eyermann cj. J Med Chem. 1999 Oct 7;42(20):4088-98. doi: 10.1021/jm990229t. J Med Chem. 1999. PMID: 10514279
A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain.
Kawahata N, Yang MG, Luke GP, Shakespeare WC, Sundaramoorthi R, Wang Y, Johnson D, Merry T, Violette S, Guan W, Bartlett C, Smith J, Hatada M, Lu X, Dalgarno DC, Eyermann CJ, Bohacek RS, Sawyer TK. Kawahata N, et al. Among authors: eyermann cj. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2319-23. doi: 10.1016/s0960-894x(01)00446-2. Bioorg Med Chem Lett. 2001. PMID: 11527723
SRC homology-2 inhibitors: peptidomimetic and nonpeptide.
Sawyer TK, Bohacek RS, Dalgarno DC, Eyermann CJ, Kawahata N, Metcalf CA 3rd, Shakespeare WC, Sundaramoorthi R, Wang Y, Yang MG. Sawyer TK, et al. Among authors: eyermann cj. Mini Rev Med Chem. 2002 Oct;2(5):475-88. doi: 10.2174/1389557023405765. Mini Rev Med Chem. 2002. PMID: 12370048 Review.
Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.
Lee ECY, McRiner AJ, Georgiadis KE, Liu J, Wang Z, Ferguson AD, Levin B, von Rechenberg M, Hupp CD, Monteiro MI, Keefe AD, Olszewski A, Eyermann CJ, Centrella P, Liu Y, Arora S, Cuozzo JW, Zhang Y, Clark MA, Huguet C, Kohlmann A. Lee ECY, et al. Among authors: eyermann cj. J Med Chem. 2021 May 27;64(10):6730-6744. doi: 10.1021/acs.jmedchem.0c02271. Epub 2021 May 6. J Med Chem. 2021. PMID: 33955740
Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.
Lam PY, Ru Y, Jadhav PK, Aldrich PE, DeLucca GV, Eyermann CJ, Chang CH, Emmett G, Holler ER, Daneker WF, Li L, Confalone PN, McHugh RJ, Han Q, Li R, Markwalder JA, Seitz SP, Sharpe TR, Bacheler LT, Rayner MM, Klabe RM, Shum L, Winslow DL, Kornhauser DM, Hodge CN, et al. Lam PY, et al. Among authors: eyermann cj. J Med Chem. 1996 Aug 30;39(18):3514-25. doi: 10.1021/jm9602571. J Med Chem. 1996. PMID: 8784449
Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies.
Jadhav PK, Woerner FJ, Lam PY, Hodge CN, Eyermann CJ, Man HW, Daneker WF, Bacheler LT, Rayner MM, Meek JL, Erickson-Viitanen S, Jackson DA, Calabrese JC, Schadt M, Chang CH. Jadhav PK, et al. Among authors: eyermann cj. J Med Chem. 1998 Apr 23;41(9):1446-55. doi: 10.1021/jm970524i. J Med Chem. 1998. PMID: 9554878
42 results